General elections were held in Chile on 21 November 2021, including presidential, parliamentary and regional elections. Voters went to the polls to elect the President of the Republic to serve a four-year term, 27 of 50 members of the Senate to serve an eight-year term in the National Congress, all 155 members of the Chamber of Deputies to serve a four-year term in the National Congress, and all 302 members of the regional boards to serve a three-year term. Following an electoral reform in 2015, the Senate increased its membership from 38 to 43 in 2017 and grew to its full size of 50 seats after this election.

The President of Chile, officially known as the President of the Republic of Chile, is the head of state and head of government of the Republic of Chile. The president is responsible for both government administration and state administration. Although its role and significance have changed over time, and its position and relations with other actors in the national political organization have also evolved, it remains one of the most prominent political offices in the country. It is also considered one of the key institutions that form the "Historic Constitution of Chile," and is crucial to the country's political stability.