The 2021 Cleveland mayoral election took place on November 2, 2021, to elect the Mayor of Cleveland, Ohio. The election was officially nonpartisan, with the top two candidates from the September 14 primary election advancing to the general election, regardless of party. Incumbent Democratic Mayor Frank G. Jackson was eligible to run for reelection to a fifth term, but instead chose to retire. Justin Bibb was elected the 58th mayor of Cleveland in the general election.

Frank George Jackson is an American lawyer and politician who served as the 56th Mayor of Cleveland, Ohio from 2006 to 2022. He was first elected on November 8, 2005, unseating incumbent Jane Campbell, and re-elected in 2009, 2013, and 2017. Having served four full terms, he is the longest-serving mayor in Cleveland history. On May 6, 2021, he announced he would not seek re-election in 2021.