The 2021 Copa CONMEBOL Libertadores Femenina was the 13th edition of the CONMEBOL Libertadores Femenina, South America's premier women's club football tournament organized by CONMEBOL.

The CONMEBOL Libertadores Femenina, commonly known as "Copa Libertadores Femenina", is an annual international women's association football club competition in South America. It is organized by the South American Football Confederation (CONMEBOL). The competition started in the 2009 season in response to the increased interest in women's football. It is the only CONMEBOL club competition for women.