The 2021 Daytona 500, the 63rd running of the event, was a NASCAR Cup Series race that was held on February 14–15, 2021 at Daytona International Speedway in Daytona Beach, Florida. Contested over 200 laps on the 2.5-mile (4.0 km) asphalt superspeedway, it was the first race of the 2021 NASCAR Cup Series season. In one of the biggest surprise upsets in Daytona 500 history, Michael McDowell, driving for Front Row Motorsports, won after Team Penske teammates Joey Logano and Brad Keselowski wrecked battling for the lead on the final lap. McDowell was a 100–1 underdog, making his 358th Cup Series start and driving for a team with only two previous Cup Series victories.

The 2021 NASCAR Cup Series was the 73rd season for NASCAR professional stock car racing in the United States and the 50th season for the modern era Cup Series. The season started at Daytona International Speedway with the Busch Clash, where it was the first year that the non-points event was run on the track's road course layout instead of the oval. That race was followed by the Bluegreen Vacations Duel qualifying races, and the 63rd running of the Daytona 500, the first points race of the season. The regular season also ended at Daytona with the 2021 Coke Zero Sugar 400 on August 28, where Kyle Larson won the Regular Season Championship. Following the 2021 Xfinity 500 at Martinsville Speedway on October 31, Chevrolet claimed its 40th Manufacturer's Championship and its first since 2015. The NASCAR playoffs ended with the NASCAR Cup Series Championship Race at Phoenix Raceway on November 7 with Larson earning his first Cup Series championship after a 10-win season.