The 2021 KNVB Cup Final was a football match between Eredivisie clubs Ajax and Vitesse, that took place on 18 April 2021 at De Kuip, Rotterdam. It was the final match of the 2020–21 KNVB Cup, the 103rd season of the annual Dutch national football cup competition.

The 2020–21 KNVB Cup, for sponsoring reasons officially called the TOTO KNVB Beker, was the 103rd season of the annual Dutch national football cup competition. It commenced on 29 August 2020 with the first of two preliminary rounds, and concluded on 18 April 2021 with the final played at De Kuip in Rotterdam.