The 2021 Major League Baseball All-Star Game was the 91st Major League Baseball All-Star Game. The game was hosted by the Colorado Rockies and played at Coors Field on July 13, with the American League (AL) defeating the National League (NL) 5–2. It was the eighth consecutive All-Star Game victory for the AL.

The Major League Baseball All-Star Game, also known as the "Midsummer Classic", is an annual professional baseball game sanctioned by Major League Baseball (MLB) and contested between the all-stars from the American League (AL) and National League (NL). Starting fielders are selected by fans, pitchers are selected by managers, and reserves are selected by players and managers.