The 2021 Major League Baseball draft took place on July 11–13, 2021. In conjunction with the 2021 Major League Baseball All-Star Game, the draft was held in Denver. The draft assigned amateur baseball players to MLB teams. The draft order was set based on the reverse order of the 2020 MLB season standings. In addition, compensation picks were distributed for players who did not sign from the 2020 MLB Draft and for teams who lost qualifying free agents. On March 26, 2020, MLB and the MLBPA reached a deal that included the option to halve the draft to 20 rounds due to the COVID-19 pandemic. MLB ultimately opted to shorten the draft to 20 rounds. In total, 612 college and high school players were drafted.

The 2021 Major League Baseball All-Star Game was the 91st Major League Baseball All-Star Game. The game was hosted by the Colorado Rockies and played at Coors Field on July 13, with the American League (AL) defeating the National League (NL) 5–2. It was the eighth consecutive All-Star Game victory for the AL.