Legislative elections were held in Mexico on 6 June 2021. Voters elected 500 deputies to sit in the Chamber of Deputies for the 65th Congress. These elections took place concurrently with the country's state elections.

The Chamber of Deputies is the lower house of the Congress of the Union, the bicameral parliament of Mexico. The other chamber is the Senate. The structure and responsibilities of both chambers of Congress are defined in Articles 50 to 70 of the constitution.