The 2021 NRL Grand Final was the conclusive and premiership-deciding game of the 2021 National Rugby League season in Australia. It was contested between the Penrith Panthers and the South Sydney Rabbitohs on Sunday 3 October at Suncorp Stadium in Brisbane. Penrith won the match 14–12 to claim their third premiership title, and their first since 2003. Penrith co-captain and halfback Nathan Cleary was awarded the Clive Churchill Medal as the official man of the match.

The South Sydney Rabbitohs are an Australian professional rugby league football club based in the Sydney suburb of Redfern that competes in the National Rugby League (NRL). They are often referred to as Souths or the Bunnies.