The 2021 Overwatch League Grand Finals was the fourth championship match of the Overwatch League (OWL), taking place on September 25, 2021. The series was the conclusion of the 2021 Overwatch League playoffs and was played between the Shanghai Dragons and the Atlanta Reign. The final was originally planned to be played at the Galen Center in Los Angeles, California; however, due to increasing threat of COVID-19 and the delta variant, the match was shifted to be played online.

The Overwatch League (OWL) was a professional esports league for the video game Overwatch, produced by its developer, Blizzard Entertainment. From 2018 to 2023, the Overwatch League followed the model of other traditional North American professional sporting leagues by using a set of permanent, city-based teams backed by separate ownership groups. The league used the regular season and playoffs format rather than promotion and relegation used commonly in other esports and non-North American leagues, with players on the roster being assured a minimum annual salary, benefits, and a portion of winnings and revenue-sharing based on team performance.