The 2021 Pakistani Senate election was held on 3 March 2021. The Election commission of Pakistan announced the election schedule on 11 February 2021. 52 of the 104 Senators had retired on 7 February 2021. After the merger of the Federally Administered Tribal Areas with Khyber Pakhtunkhawa, FATA seats were abolished and there was no election on 4 of the 8 seats. The rest of the 4 seats will be abolished in 2024. Official results of the Senate Elections were announced by the Election Commission of Pakistan on 10 March 2021.

The Pakistan Tehreek-e-Insaf is a political party in Pakistan established in 1996 by Pakistani cricketer and politician Imran Khan, who served as the country's prime minister from 2018 to 2022. The PTI ranks among the three major Pakistani political parties alongside the Pakistan Muslim League–Nawaz (PML–N) and the Pakistan People's Party (PPP), and it is the largest party in terms of representation in the National Assembly of Pakistan since the 2018 general election. With over 10 million members in Pakistan and abroad, it claims to be the country's largest political party by primary membership, as well as one of the largest political parties in the world.