The 2021 Scheldeprijs was the 109th edition of the Scheldeprijs road cycling one day race, which was held on 7 April 2021. It was a 1.Pro event on the 2021 UCI Europe Tour and the 2021 UCI ProSeries. The race, which was 194.2 kilometres (120.7 mi) long, started in Terneuzen in the Netherlands and traveled through the windy fields of Zeeland before crossing the border into Belgium and finishing in Schoten on the outskirts of Antwerp.

Danny van Poppel is a Dutch professional road racing cyclist, who rides for UCI WorldTeam Bora–Hansgrohe.