The 2021 West of England mayoral election was held on 6 May 2021 to elect the mayor of the West of England, on the same day as other local elections across the country. It was the second election for the role. The mayor was elected by the supplementary vote system.

The Mayor of the West of England is the directly elected mayor who leads the West of England Combined Authority. The body, a combined authority, is responsible for the strategic administration of the West of England, including planning, transport and skills. For this purpose the West of England is defined as the local authority areas of Bristol, South Gloucestershire, and Bath and North East Somerset. The creation of the role was agreed in 2016 as part of a devolution deal, by the then Chancellor George Osborne and the leaders of the three councils.