During the late evening of Friday, December 10, 2021, a violent, long-tracked EF4 tornado moved across Western Kentucky, producing severe to catastrophic damage in numerous towns, including Mayfield, Princeton, Dawson Springs, and Bremen. The second significant tornado in an exceedingly long-tracked tornado family, this tornado began just inside northern Obion County, Tennessee, a few miles after another long-tracked tornado – which traveled through northeast Arkansas, the Missouri Bootheel, and northwest Tennessee – dissipated in western Obion County. After crossing into Kentucky, the tornado moved through eleven counties of the Jackson Purchase and Western Coal Field regions while at times becoming wrapped in rain during its almost three-hour lifespan that covered 165.6 miles (266.5 km). It was the deadliest and longest-tracked tornado in an outbreak that produced numerous strong tornadoes in several states; 57 fatalities were confirmed in the tornado.

Mayfield is a home rule–class city and the county seat of Graves County, Kentucky, United States. The population was 10,017 as of the 2020 United States Census.