The 2022 Daytona 500 was the first stock car race of the 2022 NASCAR Cup Series and the 64th running of the event. The race was held on Sunday, February 20, 2022, in Daytona Beach, Florida at Daytona International Speedway, a 2.5-mile (4.0 km) asphalt superspeedway. In a green-white-checker finish, rookie Austin Cindric, driving for Team Penske, led 21 of the final 45 laps and held off challenges from teammate Ryan Blaney, RFK Racing's Brad Keselowski and eventual second-place finisher Bubba Wallace of 23XI Racing to win his first career NASCAR Cup Series race. Chase Briscoe of Stewart-Haas Racing finished third. Team Penske dedicated their Daytona 500 win to legendary sportscaster Bob Jenkins after the race. Jenkins used to broadcast NASCAR Races on ESPN from 1981 to 2000.

The 2022 NASCAR Cup Series was the 74th season for NASCAR professional stock car racing in the United States and the 51st season for the modern Cup Series. The 2022 season marked the debut of the Next Gen Car, which was originally supposed to debut in 2021, but was postponed due to the COVID-19 pandemic. In addition, this was the first season to have races covered by USA Network, which took over for the now-defunct NBCSN.