The 2022 Gasparilla Bowl was a college football bowl game played on December 23, 2022, at Raymond James Stadium in Tampa, Florida. The 14th annual Gasparilla Bowl began at 6:35 p.m. EST and was aired on ESPN. The game was played between the Wake Forest Demon Deacons from the Atlantic Coast Conference (ACC) and the Missouri Tigers from the Southeastern Conference (SEC). It was one of the 2022–23 bowl games concluding the 2022 FBS football season.

The Gasparilla Bowl is an annual NCAA-sanctioned post-season college football bowl game played in the Tampa Bay area. It was first played in 2008 as the St. Petersburg Bowl at Tropicana Field in St. Petersburg, Florida. The game was renamed the Gasparilla Bowl in 2017 as a nod to the legend of José Gaspar, a mythical pirate who supposedly operated in the Tampa Bay area and who is the inspiration for Tampa's Gasparilla Pirate Festival. In May 2018, the owners announced the bowl would be relocated to Raymond James Stadium in Tampa.