The 2022 M&M's Fan Appreciation 400 was a NASCAR Cup Series race that was held on July 24, 2022, at Pocono Raceway in Long Pond, Pennsylvania. Contested over 160 laps on the 2.5-mile (4.0 km) speedway, it was the 21st race of the 2022 NASCAR Cup Series season. Chase Elliott of Hendrick Motorsports would win the race after Denny Hamlin and Kyle Busch, who originally finished first and second respectively, were both disqualified for failing post-race technical inspection. Elliott became the first NASCAR driver to win a race after both the original first and second-place finishers were disqualified since 1955. Hamlin was also the first NASCAR Cup Series race winner to be disqualified since 1960, ending a 62-year streak. It was also the first disqualification of the Next Gen car since its debut earlier that year.

The 2022 NASCAR Cup Series was the 74th season for NASCAR professional stock car racing in the United States and the 51st season for the modern Cup Series. The 2022 season marked the debut of the Next Gen Car, which was originally supposed to debut in 2021, but was postponed due to the COVID-19 pandemic. In addition, this was the first season to have races covered by USA Network, which took over for the now-defunct NBCSN.