An election was held on November 8, 2022, to elect all 40 members to Massachusetts' Senate. The election coincided with elections for other offices, including governor, and U.S. House of Representatives.

The Massachusetts Senate is the upper house of the Massachusetts General Court, the bicameral state legislature of the Commonwealth of Massachusetts. The Senate comprises 40 elected members from 40 single-member senatorial districts in the state. All but one of the districts are named for the counties in which they are located. Senators serve two-year terms, without term limits. The Senate convenes in the Massachusetts State House in Boston, the state capital.