The 2022 FIM MotoGP World Championship was the premier class of the 74th F.I.M. Road Racing World Championship season. Fabio Quartararo came into the season as the defending World Champion. Ducati secured the constructors' championship, with the factory Ducati Lenovo Team securing the teams' championship and factory rider Francesco Bagnaia achieving the riders' championship. In total, seven different riders and five manufacturers won Grands Prix during the season. As the only manufacturer without a victory, the season saw Honda finish in last place of the manufacturers' standings for the first time in the modern MotoGP era.

Fabio Alain Quartararo, nicknamed El Diablo, is a French Grand Prix motorcycle rider racing in MotoGP for Monster Energy Yamaha MotoGP Team. Having won the 2021 MotoGP World Championship, he is the first French World Champion in the premier class' history.