The 2022 NBA All-Star Game was an exhibition game played on February 20, 2022, during the National Basketball Association's 2021–22 season. It was the 71st edition of the NBA All-Star Game. The game was hosted by the Cleveland Cavaliers at Rocket Mortgage FieldHouse. This was the third time that the Cleveland area hosted the All-Star Game, the first being in 1981 at the Coliseum in nearby Richfield, Ohio, and most recently in 1997—three years after the Cavaliers moved back to downtown Cleveland to play in the newly built Gund Arena, which is now known as Rocket Mortgage FieldHouse. Coincidentally, on the occasion Cleveland hosted an All-Star Game, the NBA celebrated its 35th season (1981), 50th anniversary (1997), and 75th anniversary (2022). The announcement of the site selection was made on November 1, 2018, at a press conference held by the Cleveland Cavaliers.

Rocket Mortgage FieldHouse is a multi-purpose arena in Cleveland, Ohio. The building is the home of the Cleveland Cavaliers of the National Basketball Association (NBA) and the Cleveland Monsters of the American Hockey League (AHL). It also serves as a secondary arena for Cleveland State Vikings men's and women's basketball.