The 2022 United States Senate election in Alabama was held on November 8, 2022, to elect a member of the United States Senate to represent the State of Alabama. Incumbent senator Richard Shelby was first elected in 1986 and re-elected in 1992 as a Democrat before becoming a Republican in 1994. In his most recent election in 2016, he was re-elected with nearly 64% of the vote over Democrat Ron Crumpton. In February 2021, Shelby announced that he would not seek re-election to a seventh term, which resulted in the first open Senate seat since 1996 and the first in this seat since 1968.

Richard Craig Shelby is an American lawyer and politician who served as a United States senator from Alabama from 1987 to 2023. First elected to the U.S. Senate in 1986 as a Democrat who later switched to the Republican Party in 1994, he chaired the Senate Appropriations Committee from 2018 to 2021. He previously chaired the Senate Intelligence Committee, the Senate Banking Committee, and the Senate Rules Committee. He was the longest-serving U.S. senator from Alabama, surpassing John Sparkman's record in March 2019.