The 2022 United States Senate election in Vermont was held on November 8, 2022, to elect a member of the United States Senate to represent the state of Vermont. It was held concurrently with U.S. Senate elections in other states, along with elections to the United States House of Representatives and various state and local elections across the country. The incumbent senator, Democrat Patrick Leahy, announced on November 15, 2021, that he would not seek re-election to a ninth term, leaving the seat open for the first time since 1974.

The 1974 United States Senate election in Vermont took place on November 5, 1974. The incumbent Republican Senator, George Aiken, did not run for re-election to another term in the United States Senate. The Democratic nominee, Patrick Leahy, the state's attorney of Chittenden County, defeated Republican nominee, Rep. Richard W. Mallary, to become Aiken's successor. This election also included Liberty Union Party candidate Bernie Sanders, who won 4.1% of the vote.