The 2022 Washington Nationals season was the Nationals' 18th season as the baseball franchise of Major League Baseball in the District of Columbia, the 15th season at Nationals Park, and the 54th since the original team was started in Montreal, Quebec, Canada. The Nationals failed to improve on their 65–97 record from the previous year, losing 107 games, having the worst record in the major leagues for the first time since 2009. The 107 losses came just three years after their first World Series title in 2019. It also marked the first time since 2009 that the Nationals lost 100 or more games in one season. In addition, it is the fifth time in franchise history that the Nationals lost 100 or more games, along with 1969, 1976, 2008, and 2009. To further add to Washington's dismal season, Juan Soto, along with Josh Bell, left the team via a trade to the San Diego Padres during the trade deadline.

Nationals Park is a baseball stadium along the Anacostia River in the Navy Yard neighborhood of Washington, D.C. It is the ballpark of Major League Baseball's Washington Nationals. Since its completion in 2008, it was the first LEED-certified green major professional sports stadium in the United States.