The men's 100 metres at the 2022 World Athletics Championships was held at the Hayward Field in Eugene on 15 and 16 July 2022. 76 athletes from 53 nations entered to the competition.

Marvin Bracy-Williams is an American sprinter, and a former American football wide receiver. He played college football for the Florida State Seminoles, and quit just prior to their 2013 national championship season to pursue a professional career in track. He holds personal bests of 9.85s in the 100 m and 6.44 s in the 60 m, which he set in 2022 at the 2022 World Athletics Indoor Championships in Belgrade, Serbia. He won three straight U.S. National Championships at 60 meters in 2014–16. In July 2016, Bracy came in third in the 100 meters at the U.S. Olympic Trials qualifying for the 2016 Summer Olympics.