The 21st Annual Latin Grammy Awards were held on Thursday, November 19, 2020 and broadcast on TelevisaUnivision. The 2020 Latin Grammy ceremony was anchored from the American Airlines Arena in Miami, though the health protocols enacted due to the COVID-19 pandemic meant there was no live audience in the venue, and performances were presented from remote locations from many parts of the world. The telecast marked the 21st anniversary of the Latin Grammy Awards and honored musical releases within Latin music released from June 1, 2019 to May 31, 2020. Nominations were announced on September 29.

Kaseya Center is a multi-purpose arena on Biscayne Bay in Miami, Florida. The arena was previously named American Airlines Arena from opening in 1999 until 2021, FTX Arena from 2021 until 2023 following the bankruptcy of FTX, and Miami-Dade Arena during an interim period in 2023. Since April 2023, the naming rights to the arena are owned by Kaseya under a 17-year, $117.4 million agreement.