220 Central Park South is a residential skyscraper in Midtown Manhattan in New York City, situated along Billionaires' Row on the south side of Central Park South between Broadway and Seventh Avenue. 220 Central Park South was designed by Robert A.M. Stern Architects and SLCE Architects, with interiors designed by Thierry Despont. It is composed of two sections: a 70-story, 950-foot (290 m) tower on 58th Street, which is the 21st-tallest building in New York City, as well as an 18-story section on Central Park South, both of which contain a limestone facade. Most of the 118 apartments are duplex apartments, although some of the units have been combined to create larger units. The building has a porte-cochère, a wine cellar, private dining rooms, and various recreational facilities.

Midtown Manhattan is the central portion of the New York City borough of Manhattan and serves as the city's primary central business district. Midtown is home to some of the city's most prominent buildings, including the Empire State Building, the Chrysler Building, the Hudson Yards Redevelopment Project, the headquarters of the United Nations, Grand Central Terminal, and Rockefeller Center, as well as several prominent tourist destinations including Broadway, Times Square, and Koreatown. Penn Station in Midtown Manhattan is the busiest transportation hub in the Western Hemisphere.