The 221st Cavalry Regiment, Nevada Army National Guard, is a parent regiment under the U.S. Army Regimental System, with headquarters in Las Vegas, Nevada. It currently consists of 1st Squadron, 221st Cavalry Regiment a 600-soldier Armored Reconnaissance Squadron of the Nevada Army National Guard located in southern Nevada. For command and control purposes within the Nevada Army National Guard, 1st Squadron, 221st Cavalry Regiment, is a subordinate unit to the Land Component Commander (LCC) of the Nevada Army National Guard. In 2016, the squadron entered into an alignment-for-training relationship with the 116th Cavalry Brigade Combat Team, 34th Infantry Division. In May 2016, the squadron donned the Shoulder Sleeve Insignia of the 116th Cavalry Brigade Combat Team. As an armored reconnaissance squadron, the 1st Squadron, 221st Cavalry Regiment, is able to deploy three mechanized cavalry troops, one armor company, a support company, a headquarters troop, and a squadron headquarters in order to accomplish its federal, state, and community missions.

The Nevada National Guard is the component of the United States National Guard in Nevada. The governor of Nevada may call individuals or units of the Nevada National Guard into state service. The Constitution of the United States charges the National Guard of each state to support its dual federal and state missions.