22nd Street is an east–west street passing through the Noe Valley, Mission, and Potrero Hill districts of San Francisco, California. The street is discontinuous and exists in several sections: the main western section between Hoffman Avenue and the Bayshore Freeway, a segment from Vermont Street to Wisconsin Street, a short alley off of Missouri Street, and an eastern section from Texas Street to Pier 70. Below the elevated Interstate 280 and at-grade eastern section lies 22nd Street station, Caltrain's only station beneath ground level.

Potrero Hill is a residential neighborhood in San Francisco, California. A working-class neighborhood until gentrification in the late 1990s, it is now home to mostly upper-income residents.