Since the establishment of the United States Army in 1775, three regiments have held the designation 28th Infantry Regiment. The first was a provisional unit that was constituted on 29 January 1813 and served during The War of 1812. The second was a reorganization and redesignation of 2nd Battalion, 19th Infantry Regiment on 1 October 1866 for the American Indian Wars. This incarnation of the 28th Infantry Regiment lasted until 15 March 1869, when it was consolidated back into the 19th Infantry Regiment. The third version of the 28th Infantry Regiment is the one that has the permanent designation and history, and is the one this article is about.

The 19th Infantry Regiment is a United States Army infantry regiment which is assigned to the US Army Training and Doctrine Command, with the assignment of conducting Basic and Advanced Infantry Training.