The 2nd Arkansas Infantry was an army regiment of the Confederate Army during the American Civil War. The regiment was raised in May 1861 under Colonel Thomas C. Hindman. It served throughout the war in the western theater, in the Confederate Army of Tennessee, seeing action in the Kentucky, Tennessee and Georgia campaigns. Following its depletion in numbers, the regiment was consolidated several times with other Arkansas regiments, finally merging in 1865 into the 1st Arkansas Consolidated Infantry Regiment. The regiment has no connection with the 2nd Regiment, Arkansas State Troops, which participated in the Battle of Wilson's Creek, and is also separate from the 2nd Arkansas Consolidated Infantry Regiment, which was formed in 1864 from remnants of regiments surrendered at Vicksburg and Port Hudson.

Thomas Carmichael Hindman Jr. was an American lawyer, politician, and a senior officer of the Confederate States Army during the American Civil War. Born in Knoxville, Tennessee, he later moved to Mississippi and became involved in politics. He served in the Mexican–American War from 1846 to 1848. Hindman practiced law and in 1853 was elected to the Mississippi House of Representatives. After his term expired in 1854, he moved to Helena, Arkansas where there were more opportunities for his political ambitions. Hindman opposed the Know-Nothing party and the ruling Conway-Johnson dynasty. Elected to the United States House of Representatives in 1858, he supported slavery and secession. During Reconstruction he was assassinated.