The fifth season of 30 Rock, an American television comedy series on the NBC network in the United States, began airing on September 23, 2010. NBC announced on March 5, 2010, that 30 Rock would be returning for a fifth season in the 2010–2011 television season. Beginning with episode 11, 30 Rock was moved to the 10:00 PM timeslot, but, as a consolation, was renewed earlier than the other NBC sitcoms. During this time, Tracy Morgan underwent an emergency operation, causing his character to be written out for several episodes.

"Mrs. Donaghy" is the eleventh episode of the fifth season of the American television comedy series 30 Rock, and the 91st overall episode of the series. It was written by co-executive producer Jack Burditt and directed by Tricia Brock. The episode originally aired on NBC in the United States on January 20, 2011. Guest stars in this episode include Meng Ai, Jean Brassard, Todd Buonopane, Tituss Burgess, Cheyenne Jackson, Chris Parnell, and Sherri Shepherd.