The 351st Infantry Regiment was a National Army Infantry Regiment first organized for service in World War I as part of the 88th Infantry Division in Europe. It later served in the Mediterranean Theater during World War II. Since then it has served as a training Regiment, training Army Reserve and Army National Guard Soldiers for service overseas after the September 11 terrorist attacks.

The 88th Infantry Division was an infantry division of the United States Army that saw service in both World War I and World War II. It was one of the first of the Organized Reserve divisions to be called into federal service, created nearly "from scratch" after the implementation of the draft in 1940. Previous divisions were composed of a core of either Regular Army or National Guard personnel plus draftees. Much of the experience in reactivating it was used in the subsequent expansion of the U.S. Army.