The 4080th Strategic Reconnaissance Wing is a discontinued United States Air Force (USAF) wing last assigned to the 12th Strategic Aerospace Division of Strategic Air Command (SAC) at Davis–Monthan AFB, Arizona. It was SAC's high altitude reconnaissance wing for its existence and was the first USAF wing to operate the Lockheed U-2. It was discontinued as part of a program to replace operational units controlled by major commands with those controlled by USAF whose lineages could be continued.

Davis–Monthan Air Force Base is a United States Air Force base 5 miles southeast of downtown Tucson, Arizona. It was established in 1925 as Davis–Monthan Landing Field. The host unit for Davis–Monthan AFB is the 355th Wing assigned to Twelfth Air Force (12AF), part of Air Combat Command (ACC). The base is best known as the location of the Air Force Materiel Command's 309th Aerospace Maintenance and Regeneration Group, the aircraft boneyard for all excess military and U.S. government aircraft and aerospace vehicles.