The 42nd Infantry Division Sustainment Brigade is a United States Army sustainment brigade of the 42nd Infantry Division of the New York Army National Guard headquartered out of the 369th Regiment Armory in Harlem, New York. This unit is descended from the 369th Infantry Regiment.

The New York Army National Guard is a component of the New York National Guard and the Army National Guard. Nationwide, the Army National Guard comprises approximately one half of the United States Army's available combat forces and approximately one third of its support organization. National coordination of various state National Guard units are maintained through the National Guard Bureau.