The 45th Annual Tony Awards was broadcast by CBS from the Minskoff Theatre on June 2, 1991. The hosts were Julie Andrews and Jeremy Irons.

The Minskoff Theatre is a Broadway theater on the third floor of the One Astor Plaza office building in the Theater District of Midtown Manhattan in New York City. Opened in 1973, it is operated by the Nederlander Organization and is named after Sam Minskoff and Sons, the building's developers. There are approximately 1,710 seats in the auditorium, spread across an orchestra level and a balcony. Over the years it has hosted musicals, dance companies, and concerts.