50/50 is a 2011 American comedy-drama film directed by Jonathan Levine, written by Will Reiser, and starring Joseph Gordon-Levitt, Seth Rogen, Anna Kendrick, Bryce Dallas Howard, and Anjelica Huston. The film is loosely inspired by Reiser's own experience with cancer, with Rogen's character Kyle based on Rogen himself. It was filmed from February to March 2010.

Joseph Leonard Gordon-Levitt is an American actor. He has received various accolades, including nominations for the Golden Globe Award for Best Actor – Motion Picture Musical or Comedy for his leading performances in 500 Days of Summer (2009) and 50/50 (2011). He is the founder of the online media platform HitRecord whose projects such as HitRecord on TV (2014–15) and Create Together (2020) won him two Primetime Emmy Awards in the category of Outstanding Interactive Program.