The 58th Golden Globe Awards, honoring the best in film and television for 2000, were held on January 21, 2001. The nominations were announced on December 21, 2000.

Nurse Betty is a 2000 American black comedy film directed by Neil LaBute and starring Renée Zellweger as the title character, a small town, Kansas housewife-waitress who suffers a nervous breakdown after witnessing her husband's torture murder, and starts obsessively pursuing her favorite television soap opera character, while in a fugue state. Morgan Freeman and Chris Rock play the hitmen who killed her husband and subsequently pursue her to Los Angeles.