The 58th Primetime Emmy Awards were held on Sunday, August 27, 2006, at the Shrine Auditorium in Los Angeles, California on NBC at 8:00 p.m. ET with Conan O'Brien hosting the show. The ceremony attracted 16.2 million viewers, 2.5 million fewer than the previous year's ceremony, but still the ratings winner for the week. The Discovery Channel received its first major nomination this year.

Conan Christopher O'Brien is an American television host, comedian, writer, and producer. He is best known for having hosted late-night talk shows, beginning with Late Night with Conan O'Brien (1993–2009) and The Tonight Show with Conan O'Brien (2009–2010) on the NBC television network, and Conan (2010–2021) on the cable channel TBS. Before his hosting career, O'Brien was a writer for the NBC sketch comedy series Saturday Night Live from 1988 to 1991, and the Fox animated sitcom The Simpsons from 1991 to 1993. He has also been host of the podcast series Conan O'Brien Needs a Friend since 2018 and starred in the 2024 travel show Conan O'Brien Must Go on Max.