The 5th Avenue Theatre is a landmark theatre located in the Skinner Building, in the downtown core of Seattle, Washington, United States. It has hosted a variety of theatre productions and motion pictures since it opened in 1926. The building and land are owned by the University of Washington and were once part of the original campus. The theatre operates as a venue for nationally touring Broadway and original shows by the non-profit 5th Avenue Theatre Association.

The Skinner Building is an eight-story building in Seattle, in the U.S. state of Washington, which includes the historic 5th Avenue Theatre at its southern end. Part of the Metropolitan Tract, the structure is listed on the National Register of Historic Places for the architecture of the interior theatre and of the rest of the building. The exterior features an unadorned sandstone facade with a false loggia and red mission tile roof.