Ngawang Lobsang Gyatso was the 5th Dalai Lama and the first Dalai Lama to wield effective temporal and spiritual power over all Tibet. He is often referred to simply as the Great Fifth, being a key religious and temporal leader of Tibetan Buddhism and Tibet. Gyatso is credited with unifying all Tibet under the Ganden Phodrang after a Mongol military intervention which ended a protracted era of civil wars. As an independent head of state, he established relations with the Qing empire and other regional countries and also met early European explorers. Gyatso also wrote 24 volumes' worth of scholarly and religious works on a wide range of subjects.

Dalai Lama is a title given by the Tibetan people to the foremost spiritual leader of the Gelug or "Yellow Hat" school of Tibetan Buddhism, the newest and most dominant of the four major schools of Tibetan Buddhism. The 14th and incumbent Dalai Lama is Tenzin Gyatso, who lives in exile as a refugee in India. The Dalai Lama is considered to be the successor in a line of tulkus who are believed to be incarnations of Avalokiteśvara, the Bodhisattva of Compassion.