The 5th Regiment, Arkansas State Troops (1861) was an Arkansas State infantry regiment that served during the American Civil War. Formed in mid-1861, the regiment was assigned to the command of Brigadier General Nicholas Bartlett Pearce, commander, 1st Division, Provisional Army of Arkansas. It was disbanded after the Battle of Wilson's Creek in August 1861. Another Arkansas unit also had the designation 5th Arkansas, the 5th Arkansas Infantry Regiment which belonged to the Confederate Army of Tennessee. There is no connection between the two units.

Nicholas Bartlett Pearce was a brigadier general in the Arkansas State Troops during the American Civil War. He led a brigade of infantry in one of the war's earliest battles in the Trans-Mississippi Theater before serving as a commissary officer in the Confederate States Army for the rest of the war.