The 67th David di Donatello ceremony, presented by the Accademia del Cinema Italiano, honored the best in Italian cinema released from 1 March 2021 to 28 February 2022 at Cinecittà Studios in Rome. The ceremony was hosted by presenters Carlo Conti and Drusilla Foer.

The Hand of God is a 2021 Italian semi-autobiographical drama film written, directed and produced by Paolo Sorrentino. Set in Naples, the film delves into Sorrentino's own youth. Its cast features Filippo Scotti, Toni Servillo, Teresa Saponangelo, Marlon Joubert, Luisa Ranieri, Renato Carpentieri, Massimiliano Gallo, Betti Pedrazzi, Enzo Decaro, Sofya Gershevich, Lino Musella and Biagio Manna.