The 6th Screen Actors Guild Awards, honoring the best achievements in film and television performances for the year 1999, took place on March 12, 2000. The ceremony was held at the Shrine Exposition Center in Los Angeles, California, and was televised live by TNT.

Girl, Interrupted is a 1999 American biographical psychological drama film written and directed by James Mangold, from a screenplay by Mangold, Lisa Loomer, and Anna Hamilton Phelan, and based on the 1993 memoir of the same name by Susanna Kaysen. Starring Winona Ryder, Angelina Jolie, Clea DuVall, Brittany Murphy, Elisabeth Moss, Jared Leto, Angela Bettis, Jeffrey Tambor, Vanessa Redgrave, and Whoopi Goldberg, the film follows a young woman who spends 18 months institutionalized at a psychiatric hospital following a suicide attempt.