The 8th Missouri Infantry Regiment was an infantry regiment of the Confederate States Army during the American Civil War. From May 1861, the war began affecting events in the state of Missouri. In 1862, Confederate recruiting activities took place in Missouri, and a cavalry regiment was formed in Oregon County, the nucleus being former members of the Missouri State Guard. On September 2, the unit entered Confederate service, but it was reclassified as infantry ten days later. After many of the men transferred to other units, the regiment was reclassified as a battalion on October 19 and named the 7th Missouri Infantry Battalion, also known as Mitchell's Missouri Infantry. It participated in a Confederate offensive at the Battle of Prairie Grove on December 7. During the battle, the unit made several charges against the Union lines but was repeatedly repulsed by artillery fire. The regiment spent most of early 1863 encamped near Little Rock and Pine Bluff in Arkansas.

The Little Rock Campaign, officially known as Advance of the Union forces upon Little Rock, Arkansas, was a campaign conducted by the Union Army in Arkansas during the American Civil War. The offensive was designed to capture Little Rock.