The A4010 is an important primary north–south road in Buckinghamshire, Southern England. It runs from High Wycombe at Junction 4 of the M40 motorway to Stoke Mandeville, near Aylesbury on the A413.

High Wycombe, often referred to as Wycombe, is a market town in Buckinghamshire, England. Lying in the valley of the River Wye surrounded by the Chiltern Hills, it is 29 miles (47 km) west-northwest of Charing Cross in London, 13 miles (21 km) south-southeast of Aylesbury, 23 miles (37 km) southeast of Oxford, 15 miles (24 km) northeast of Reading and 8 miles (13 km) north of Maidenhead.