The A57 is a major road in England. It runs east from Liverpool to Lincoln via Warrington, Salford and Manchester, and then through the Pennines over the Snake Pass (between the high moorlands of Bleaklow and Kinder Scout), around the Ladybower Reservoir, through Sheffield and past Worksop. Between Liverpool and Glossop, the road has largely been superseded by the M62, M602 and M67 motorways. Within Manchester a short stretch becomes the Mancunian Way, designated A57(M).

The A580 is the United Kingdom's first purpose-built A road. The road was officially opened by King George V on 18 July 1934. Despite its name, the actual road runs through the modern day metropolitan counties of Merseyside and Greater Manchester which were historically in Lancashire when the road was built until 1974. Notable towns and cities along the route include Liverpool, Kirkby, St. Helens, Leigh, Swinton and Salford.