The ACC–Big Ten Challenge was an in-season NCAA Division I men's college basketball series that matched up teams from the Atlantic Coast Conference (ACC) and the Big Ten Conference (B1G). ESPN was a key part of the creation of the challenge and held the broadcast rights to all the games. The ACC–Big Ten Challenge occurred early in the non-conference season, typically around late November/early December. Each game was hosted by one of the participating schools, with teams typically alternating home and away status in each successive year.

The Atlantic Coast Conference (ACC) is a collegiate athletic conference located in the United States. Headquartered in Charlotte, North Carolina, the ACC's fifteen member universities compete in the National Collegiate Athletic Association (NCAA)'s Division I. ACC football teams compete in the NCAA Division I Football Bowl Subdivision. The ACC sponsors competition in twenty-seven sports with many of its member institutions held in high regard nationally. Current members of the conference are: Boston College, Clemson, Duke, Florida State, Georgia Tech, Louisville, Miami, North Carolina, NC State, Notre Dame, Pittsburgh, Syracuse, Virginia, Virginia Tech, and Wake Forest.