A Guide to the Scientific Knowledge of Things Familiar, also known as The Guide to Science or Brewer's Guide to Science, is a book by Ebenezer Cobham Brewer presenting explanations for common phenomena. First published in the United Kingdom around 1840, the book is laid out in the style of a catechism and proved very popular. 47 editions were printed by 1905 in English alone and translations made into various other languages. A revised version was produced for the US market which was digitised and republished in 2005 as part of Making of America IV: the American voice, 1850–1877.

Ebenezer Cobham Brewer, was a British lexicographer and the author of A Guide to the Scientific Knowledge of Things Familiar, Brewer's Dictionary of Phrase and Fable, and The Reader's Handbook, among other reference books.