A Lie of the Mind is a play written by Sam Shepard, first staged at the off-Broadway Promenade Theater on 5 December 1985. The play was directed by Shepard himself with stars Harvey Keitel as Jake, Amanda Plummer as Beth, Aidan Quinn as Frankie, Geraldine Page as Lorraine, and Will Patton as Mike. The music was composed and played by the North Carolina bluegrass group the Red Clay Ramblers.

Samuel Shepard Rogers III was an American actor, playwright, author, director and screenwriter whose career spanned half a century. He won 10 Obie Awards for writing and directing, the most by any writer or director. He wrote 58 plays as well as several books of short stories, essays, and memoirs. Shepard received the Pulitzer Prize for Drama in 1979 for his play Buried Child and was nominated for an Academy Award for Best Supporting Actor for his portrayal of pilot Chuck Yeager in the 1983 film The Right Stuff. He received the PEN/Laura Pels Theater Award as a master American dramatist in 2009. New York magazine described Shepard as "the greatest American playwright of his generation."