A Prairie Home Companion is a 2006 American musical comedy film directed by Robert Altman and is his final film. It is a fictional representation of behind-the-scenes activities at the long-running public radio show of the same name. The film received mostly positive reviews and was a moderate box-office success on a small budget. The film features an ensemble cast including Woody Harrelson, Tommy Lee Jones, Garrison Keillor, Kevin Kline, Lindsay Lohan, Virginia Madsen, John C. Reilly, Maya Rudolph, Meryl Streep, and Lily Tomlin.

A Prairie Home Companion is a weekly radio variety show created and hosted by Garrison Keillor that aired live from 1974 to 2016. In 2016, musician Chris Thile took over as host, and the successor show was eventually renamed Live from Here and ran until 2020. A Prairie Home Companion aired on Saturdays from the Fitzgerald Theater in Saint Paul, Minnesota; it was also frequently heard on tours to New York City and other U.S. cities. The show is known for its musical guests, especially folk and traditional musicians, tongue-in-cheek radio drama, and relaxed humor. Keillor's wry storytelling segment, "News from Lake Wobegon," was the show's best-known feature during his long tenure.